Buccal Absorption: How Gummies Begin Their Journey

Buccal Absorption: How Gummies Begin Their Journey

Your mouth does more than taste — it can also absorb. Known as buccal absorption, the mucous membranes of the mouth allow the uptake of certain nutrients from the first chew. 

Unlike tablets that bypass the oral mucosa, gummies offer a potential head start in nutrient delivery.

This process is known as buccal absorption.

Let’s take a closer look at what it is and why gummies are such a convenient way to support your daily wellness routine.

What Is Buccal Absorption?

Buccal absorption refers to the process where nutrients are absorbed directly through the tissues in your mouth (especially the inner cheeks and under the tongue) rather than going through your digestive system first. ⁽¹⁾

By starting absorption in the mouth, then continuing in the GI tract and only then passing on to the liver (where many nutrients are broken down or filtered), buccal absorption allows for more efficient delivery of some nutrients.

How Does Buccal Absorption Work?

Your mouth isn’t just for chewing and chatting, it’s lined with thin mucous membranes packed with capillaries. When nutrients dissolve in the mouth and come into contact with these membranes, they can diffuse directly into your bloodstream via these tiny blood vessels.

Buccal Absorption Explained

Here's how it works:

  1. 1️⃣ Contact: Nutrients contact the mucosa in your mouth.
  2. 2️⃣ Diffusion: Small, soluble molecules pass through the mucosal membrane.
    1. 💦 Water-soluble vitamins like vitamin C & B can diffuse easily and are absorbed quickly.
    2. ☀️ Fat-soluble vitamins like vitamin D require special carriers (like glucose) to cross effectively.
  3. 3️⃣ Circulation: These molecules enter your bloodstream and travel where needed, without detouring through the stomach or liver first.

 

This method is particularly beneficial for nutrients that:

  • 👉 Are poorly absorbed in the gut
  • 👉 Are sensitive to stomach acid
  • 👉 Are rapidly broken down by the liver during digestion (a process called first-pass metabolism)

 

What Is First-Pass Metabolism?

When you swallow a pill, it doesn’t go straight into your bloodstream. 

First, it travels through your digestive system, where some of the nutrients are lost along the way. 

What’s left is filtered through the liver, a process known as first-pass metabolism, which can break down part of the active ingredients. ⁽²⁾

Only a portion of the original dose makes it into your bloodstream, meaning your body may absorb less than you think.

First Pass Metabolism

➡️ This liver detour is known as first-pass metabolism.

Gummies start their journey by taking advantage of buccal absorption first, then moving to the GI tract and only then passing to the liver. 

Why Gummies Make Sense

Unlike traditional tablets or capsules, gummies spend more time in your mouth, where they start dissolving and interacting with the oral mucosa. That makes them ideal for buccal absorption, especially for nutrients designed to work quickly or in smaller, targeted doses.

Consistency is one of the most important parts of any supplement routine, and taking a supplement you enjoy can make it easier to build that habit.

Gummies are often chosen because they are:

  • ✔ easy to chew
  • ✔ convenient for everyday use
  • ✔ designed to dissolve before swallowing
  • ✔ a simple alternative to large tablets or capsules
  • ✔ easy to include in your daily routine

 

Nutrients That Love Buccal Absorption

Vitamin C

Vitamin C is a key nutrient for immune support and your mouth can absorb it directly. ⁽⁷⁾

Novomins Vitamin C Gummies

Studies show that ascorbic acid can pass through the buccal mucosa, making it a perfect fit for gummies that dissolve in the mouth.⁽³⁾

Benefits of Vitamin C

As a water-soluble vitamin, vitamin C is commonly used in chewable supplement formats, making gummies a convenient way to include it as part of your daily routine.

Vitamin B12

⁽⁷⁾ Vitamin B12 supports your energy, general health and red blood cell production, but it’s notoriously difficult to absorb through the gut. That’s where buccal absorption shines.

Novomins Energy Vitamin B12 Gummies

Studies show that delivering B12 through the inner cheek, via dissolvable formats like gummies, significantly increases absorption compared to traditional capsules or tablets. ⁽⁴⁾

Novomins Energy Vitamin B12 Gummies

Vitamin D

Vitamin D is known to support immune health, muscle health, and healthy bones, but many people, especially those with digestive issues, don’t absorb it well from food or pills. ⁽⁷⁾

Luckily, research shows that buccal delivery is far more effective.

Novomins High Strength Vitamin D Gummies

One study found that vitamin D3 delivered through a buccal spray raised blood levels 1.9x higher in healthy people, and 2.6x higher in those with malabsorption, compared to softgel capsules.⁽⁵⁻⁶⁾

Novomins High Strength Vitamin D Gummies

Why Buccal Absorption Matters

Research continues to explore how different nutrients interact with the body depending on the supplement format.

Because gummies are chewed before swallowing, they naturally spend time in the mouth where ingredients begin dissolving before continuing through the normal digestive process.

At Novomins Australia, our gummies are formulated to provide a convenient way to support your daily vitamin intake.

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Disclaimer

The information in this article is intended for general educational purposes only and is not a substitute for professional medical advice, diagnosis or treatment.

Always read the label and follow the directions for use.

If symptoms persist, talk to your health professional.

Complementary medicines should be used in conjunction with a balanced diet and healthy lifestyle.

FAQ

Why choose Novomins?
We believe looking after your health shouldn’t feel complicated. That’s why we create convenient gummy supplements that are easy to include in your everyday routine, with formulations designed to support your health and wellbeing in line with their approved indications.

Why are vitamins and minerals important?
Vitamins and minerals help support many normal processes throughout the body. Eating a balanced diet remains the best way to obtain these nutrients, while supplements can help when dietary intake is inadequate.

What does it mean when a product is TGA listed?
TGA-listed complementary medicines are regulated by the Therapeutic Goods Administration (TGA). This means they must meet Australian requirements for quality and safety, and sponsors must hold evidence to support their permitted indications.

Why do wellness routines matter?
Healthy habits are built through small, consistent actions. Eating well, staying active, getting enough sleep and taking your supplements as directed all contribute to supporting your overall health and wellbeing.

Can I combine different Novomins gummies?
Many people choose different supplements to support different aspects of their wellbeing. Always read the label and follow the directions for use, and speak with your healthcare professional if you’re unsure which products are suitable for you.

How long does it take to notice a difference?
Everyone is different. Supplements support normal body functions over time, so consistency is key. Always follow the directions for use and speak with your healthcare professional if you have questions about your individual needs.

What makes Novomins different?
Every Novomins formula is carefully developed using thoughtfully selected ingredients and manufactured to Australian quality standards. We focus on creating convenient daily supplements that fit into real life.

Why did Novomins choose gummies instead of tablets?
We believe supporting your health should be something you look forward to. Gummies are convenient, easy to take and fit naturally into everyday routines, making it easier to stay consistent with your supplements.

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References

  1. Herman TF, Santos C. First-Pass Effect. [Updated 2023 Nov 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551679/
  2. Sabra R, Kirby D, Chouk V, Malgorzata K, Mohammed AR. Buccal Absorption of Biopharmaceutics Classification System III Drugs: Formulation Approaches and Mechanistic Insights. Pharmaceutics. 2024 Dec 6;16(12):1563. doi: 10.3390/pharmaceutics16121563. PMID: 39771541; PMCID: PMC11676059. 
  3. Sadoogh-Abasian F, Evered DF. Absorption of vitamin C from the human buccal cavity. Br J Nutr. 1979 Jul;42(1):15-20. doi: 10.1079/bjn19790085. PMID: 486391. 
  4. Grammatikopoulou MG, Gkiouras K, Nigdelis MP, Bogdanos DP, Goulis DG. Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials. Nutrients. 2020 Mar 4;12(3):691. doi: 10.3390/nu12030691. PMID: 32143526; PMCID: PMC7146176.
  5. Satia et al. Nutrition Journal (2015) 14:114 DOI 10.1186/s12937-015-0105-1 
  6. Journal of Pharmaceutical Sciences, V106: I7
  7. Therapeutic Goods Administration (Australia)

AUTHORED BY

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Peter McQuillan
Founder & Chief Formulator

 

REVIEWED BY

image

Akil Memishi
Founder & Chief Clinical Researcher

 

Review Date:

7 July 2026

Next Review:

6 July 2028

 

Published On:
7 July 2026

Last Updated:
7 July 2026

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